Microbial infections till date remain a scourge of humanity due to lack of vaccine against some infections, emergence of drug\nresistant phenotypes, and the resurgence of infections amongst others. Continuous quest for novel therapeutic approaches remains\nimperative. Here we (i) assessed the effects of extracts/hydro lates of some medicinal plants on pathogenic microorganisms and\n(ii) evaluated the inhibitory potential of the most active ones in combination with antibiotics. Extract E03 had the highest DZI\n(25 mm). Extracts E05 and E06 were active against all microorganisms tested.The MICs and MBCs of the methanol extracts ranged\nfrom 16.667 Ã?â?? 103\n????g/mL to 2 ????g/mL and hydro lates from 0.028 to 333333 ppm. Extract E30 had the highest activity especially\nagainst S. saprophyticus (MIC of 6 ppm) and E. coli (MIC of 17 ppm). Combination with conventional antibiotics was shown to\novercome resistance especially with E30. Analyses of the extracts revealed the presence of alkaloids, flavonoids, triterpenes, steroids,\nphenols, and saponins. These results justify the use of these plants in traditional medicine and the practice of supplementing\ndecoctions/concoctions with conventional antibiotics. Nauclea pobeguinii (E30), the most active and synergistic of all these extracts,\nand some hydro lates with antimicrobial activity need further exploration for the development of novel antimicrobials.
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